10 Best Cream For Hand Foot And Mouth Disease [2025]

This post contains affiliate links. As an Amazon Associate, we earn from qualifying purchases.

Finding the right cream for hand, foot, and mouth disease can be a daunting task, especially with the myriad of products available on the market today. The discomfort and irritation caused by this viral infection can make it difficult for both children and adults to find relief. With so many options to choose from, it’s easy to feel overwhelmed and uncertain about which cream will truly provide the best results. Each product claims to be effective, but distinguishing between genuine solutions and mere marketing hype can be challenging when you’re navigating this on your own.

To ease your search and simplify the decision-making process, we have meticulously shortlisted ten of the best creams specifically formulated for hand, foot, and mouth disease. Our selection is based on thorough research, expert recommendations, and user reviews, ensuring that each product meets essential criteria for effectiveness and safety. By relying on our carefully curated list, you can save precious time and avoid the hassle of trial and error, allowing you to focus on what truly matters: finding relief and comfort during this uncomfortable experience.

Top 10 Best Cream For Hand Foot And Mouth Disease In The Market

Last update on 2025-06-27 / Affiliate links / Images from Amazon Product Advertising API

Best Cream For Hand Foot And Mouth Disease Reviews

Bestseller No. 1
Tea Tree Oil Balm, Foot Itch Relief Cream, Armpit Rash, Athlete's Foot, Hand...
  • Centuries-old tradition: has a long history of use in the United States and has been passed down through generations. Developed by a professor of dermatology, this cream has stood the test of time and continues to be a trusted care for a range of skin conditions.
  • Lavender and eucalyptus formula: Our eczema cream contains a unique blend of natural ingredients, including lavender and eucalyptus, which have been used for centuries to care for the skin. 100% organic and natural tea tree, eucalyptus, and lavender oil - Our premium care tea tree cream contains skin moisturizing Omega 3,6,7,9, and Vitamin E & C which help the skin repair itself and reduce redness and itching.
  • Versatile Care: Soothing relief from itchy, cracked - Our tea tree cream helps relieve jock itch, itchy feet, scaling, itching spots, redness, razor burn, rash, saddle sores, split cracked cuticles, severely chapped lips, psoriasis, dry hands, and dry feet. Our non-greasy skin ointment formula promotes healthy & soft skin to your hands, elbows, feet, heels, fingernails, toenails, scalp, and other parts of the body.
  • Relapse control & Quick-acting formula: Formulated to provide long-term relief and control of eczema and other skin conditions. Our relapse control formula is designed to prevent future outbreaks, keep skin healthy and moisturized, and provide lasting relief from symptoms, The fast-acting formula penetrates deep into the skin to provide relief and promote healing, We understand the frustration and inconvenience of recurring ringworm, and we're here to help you break the cycle.
  • Premium organic-grade tea tree, eucalyptus, and lavender essential oils make up a powerful multifunctional treatment for the whole family. We are a family workshop located on a farm, dedicated to providing you with natural, Organic, carefully crafted by hand, ensuring their purity and uniqueness, We offer a 90-day refund guarantee. If you're not completely satisfied with your purchase, simply contact us within 90 days, and we will provide a full refund.
Bestseller No. 2
UltimateVitality Hand Foot Cream for For Oncology Patients, Intensive Natural...
  • ONCOLOGY NURSE FORMULATED – Our natural and organic herbal oncology cream is formulated with powerful herbal ingredients to help moisturize, soothe and hydrate skin during chemotherapy treatment. Our oncology cream helps comfort painful swollen dry, itchy irritated skin and calms hand foot syndrome. It is also a amazing body cream to help nourish, hydrate and maintain soft healthy skin during treatment.
  • PLANT-RICH HERBAL CREAM : Our oncology hand foot cream quickly absorbs to form a hydrating skin barrier and helps heal red, dry, cracked skin. Experience smooth, soft, and calm skin with 12 skin-nourishing ingredients from nature including Aloe Vera Leaf Juice, Safflower Seed Oil, Shea Butter, Vitamine, comfrey root and cucumber extract.
  • LIGHTWEIGHT, NON-GREASY FORMULA: Dry skin is uncomfortable and itchy. This oncology cream is a superior skin nourishing, hydrating and calming formula that penetrates easily and absorbs into the most stubborn places. Smooth it all over your hands, feet and body for instant, lasting relief and hydration without worrying about leaving an oily residue.
  • CALMS AND SOOTHES DRY IRRITATED SKIN: Our natural botanical cream helps naturally calms and help heal dry, itchy irritated skin. carefully selected plant botanicals are ultra moisturizing and aid the skin in regenerating and repairing itself.
  • MADE IN USA & FULL GUARANTEE - This herbal blend was created by a oncology nurse in partnership with a top herbal skin care professional. All our herbal Ingredients are grown and manufactured in USA.
Bestseller No. 3
O'Keeffe's for Healthy Feet Foot Cream - 6.4 oz Jar (1 Pack) - Guaranteed Relief...
  • Get your feet back: O’Keeffe’s Healthy Feet is a concentrated foot cream that heals, relieves and repairs extremely dry, cracked feet; From the #1 foot cream brand in America*
  • Guaranteed relief for extremely dry feet: Creates a protective layer on the skin's surface, locking in moisture to keep even the driest, cracked feet feeling hydrated and healthy
  • Hard working foot care: Intense but soothing, our moisturizing cream instantly boosts and retains moisture levels for long term foot care
  • Recommended use: Apply the exfoliating foot cream at bedtime and after bathing, as these are known to be the most effective times for moisturizing extremely cracked, dry feet
  • Hypoallergenic: O'Keeffe's for Healthy Feet is unscented, non-greasy and safe for people with diabetes; Our 6.4 ounce jar is perfect for a reliable at-home supply of comfort and moisture
Bestseller No. 4
Reconval B6 Cream Protecting the Skin Against Post-radiotherapy Inflammation and...
  • PROTECTING THE SKIN AGAINST POST-RADIOTHERAPY SKIN INFLAMMATION OR HAND-FOOT SYNDROME
  • Restores the hydrolipidic layer of skin and maintains its pH.
  • Soothes dry, cracked, peeling fingertips and blisters on hands and feet.
  • Active ingredients: Vitamin B6 and Urea
Bestseller No. 5
Dr Scholl's Dry, Cracked Foot Repair Ultra-Hydrating Foot Cream Moisturizer, 3.5...
  • PROFESSIONAL STRENGTH FORMULA: Dr. Scholl's Dry, Cracked Foot Repair Ultra-Hydrating Foot Cream features a potent blend of 25% Urea, essential oils, and Epsom salt, specifically formulated to smooth and soften the toughest dry, cracked feet.
  • INTENSIVE MOISTURIZATION: Enriched with a high concentration of urea (25%), this moisturizer provides exceptional softening and moisturizing qualities, drawing moisture deep into the skin for up to 24 hours of hydration.
  • DEEP HEALING: This moisturizer offers profound hydration to heal and repair dry, cracked skin, revitalizing your feet with every application.
  • RESTORATIVE CARE: Designed to restore the skin’s natural moisture balance, this foot cream reveals soft, healthy feet by replenishing essential hydration.
  • SOOTHING RELIEF: Infused with levels of Epsom salt akin to a therapeutic soaking bath and blended with calming essential oils like peppermint, lavender, and eucalyptus, this foot cream penetrates deeply to soothe irritated, dry skin.
Bestseller No. 6
Majestic Pure Tea Tree Oil Foot Cream, Warming Cream - Calluses, Dry Cracked...
  • Majestic Pure Tea Tree Oil Foot Cream is made with 100% pure and natural Tea Tree essential oil that helps soothe.
  • Its formulation combines Tea Tree oil with Aloe Vera Extract, Centella Asiatica Extract, Menthol & Spearmint oil to support moisturized and soft skin.
  • Crafted with carefully selected skin-soothing ingredients, this cream helps in rejuvenation so you feel your best.
  • Gentle on the skin, this cream is suitable for all bodies and skin types and is very quickly absorbed.
  • Premium quality: We are proud to present high quality, PETA certified products featuring potent and pure plant extracts to help you feel your best.
Bestseller No. 7
42% Urea Cream for Dry & Cracked Skin - Foot & Hand Cream with 2% Salicylic...
  • Packed with 42% Urea, this cream helps repair cracked, rough skin by exfoliating and deeply hydrating layers beneath. Ideal for feet, heels, hands, elbows, and knees.
  • Infused with 2% Salicylic Acid, it softens calluses and smooths dry patches, leaving your skin feeling refreshed, softer, and healthier with each application.
  • 5% Vitamin E offers antioxidant benefits, protecting your skin from dryness while boosting its natural elasticity and suppleness for a smoother, rejuvenated look.
  • Aloe Vera calms and soothes skin, while Shea Butter locks in moisture, ensuring long-lasting hydration for even the driest, most dehydrated areas.
  • Tea Tree Oil revitalizes your skin and provides soothing benefits, leaving it feeling fresh, calm, and restored with a natural, rejuvenated appearance.
Bestseller No. 8
GENIUS Neuropathy Nerve Relief Cream with Arnica and Vitamin B6 - Maximum...
  • Expertly Formulated – Genius Neuropathy Cream is formulated to provide soothing relief to sensitive sensations, while moisturizing and nourishing targeted areas of the skin.
  • Powerful Concentrate – Our cream is packed with the highest quality ingredients that are chosen for their ability help soothe the skin. Harnessed with key actives such as Arnica, Vitamin B6, Vitamin E, MSN, & Menthol that are hand-picked to help improve personal discomfort.
  • Soothing Relaxation – We believe in the power of nature, and our cream contains only the best to provide you with targeted relief while allowing for maximum and long-lasting benefits with minimal use.
  • Quick Absorption – Enriched with a premium complex designed for fast absorption, our cream aims to provide targeted relief. Use on your back, neck, knee, hip, shoulders, elbows, joints, and muscles.
  • Your Experience is Valued – Our goal is to improve your life by reducing discomfort. If for any reason you are not completely satisfied, please reach out to us, and we will make it right!
Bestseller No. 9
40% Urea Cream for Feet with 2% Salicylic Acid Aloe Tea Tree Oil for Skin -...
  • Urea Moisturizer with Spa Socks: our urea 40% cream for feet comes with 2 reusable Spa Socks that boost urea lotion's effectiveness, acting as hand and foot mask by locking in moisture after applying our athlete foot cream for women & men
  • Soft Feet, Fast and Easy: if you need a foot moisturizer for dry cracked feet, try this urea cream foot cream for calluses and dry feet, as Urea 40 plus salicylic acid 2 % deliver powerful hydration and can act as athletes foot treatment
  • Youthful Skin Everywhere: urea body cream is not just foot lotion for dry cracked feet, as urea is a universal barrier repair moisturizer that can be used as hand lotion for dry skin as well as hand and nail cream & anywhere on your body
  • Hand and Foot Exfoliator: no need for separate hand and foot peeling mask; aside from hydrating foot care, our foot cream for dry cracked heels and feet assists in dead skin removal for feet and hands, acts as foot callus remover for feet too
  • 3 Powerful Reinforcements: urea cream 40% is reinforced with Tea Tree oil like in Tea Tree Foot Cream for dry feet, 2% Salicylic Acid Moisturizer, and Aloe Vera to deliver the most potent hydration, cracked heel treatment, and active skin repair
Bestseller No. 10
Foot Cream with Urea + Salicylic Acid & Dead Sea Minerals – Intensive Foot...
  • Ultimate Foot Repair Cream for Dry, Cracked Heels & Feet – Deeply Moisturizing Foot Cream for Dry Cracked Skin, Enriched with Dead Sea Minerals. Ideal for Heel Repair & Treatment, Restoring Smooth, Healthy Feet All Day.
  • Powerful Urea Foot Cream for Calluses & Cracked Heels – Intensive Heel Treatment Softens & Repairs Dry, Rough Feet. This Cream for Feet Provides Deep Moisture for Cracked Heel Repair & Callus Care, Restoring Smooth, Healthy Skin.
  • Effective Urea Cream for Feet Treatment – Powerful Formula for Dry, Cracked Feet, Calluses & Athlete’s Foot. This Cracked Heel Repair Cream with Salicylic Acid Exfoliates, Softens & Restores Smooth, Healthy Skin for Lasting Hydration & Relief.
  • Extra Strength Athlete’s Foot Treatment – Intensive Urea Foot Repair Cream with Salicylic Acid & Dead Sea Minerals. This Cracked Feet Treatment Hydrates Dry Feet, Soothes Cracked Heels & Restores Soft, Healthy Skin.
  • Deep Moisturizing Foot Care Solution – Enriched Foot Moisturizer for Calluses, Dry Feet & Cracked Heels. Infused with Urea & Dead Sea Minerals, It Provides Long-Lasting Hydration for Smooth, Soft & Rejuvenated Feet.

Last update on 2025-06-27 / Affiliate links / Images from Amazon Product Advertising API

The Bottom Line

In conclusion, selecting the best cream for hand foot and mouth disease is crucial for alleviating discomfort and promoting healing in affected individuals. The ten products highlighted in this article were meticulously chosen based on their effectiveness, ingredient quality, user reviews, and recommendations from healthcare professionals. Each cream offers unique benefits, whether it’s soothing pain, reducing inflammation, or providing moisture to irritated skin. We considered a variety of factors, including formulation, ease of application, and suitability for all ages, to ensure that our selections meet diverse needs.

By following our list of the best creams for hand foot and mouth disease, you can make an informed decision that enhances comfort and expedites recovery. Whether you are a parent seeking relief for a child or an adult experiencing symptoms, these products are designed to address the specific challenges posed by the disease. Using our recommendations will not only help in managing symptoms effectively but also contribute to a quicker return to everyday activities. Remember, while topical creams can provide significant relief, consulting a healthcare professional for comprehensive care is always advisable.

Pamela Couch

I am a designer, shoe-obsessed lifestyle expert, and founder of https://footwind.net/, a shoe boutique located in Downtown Atlanta. I love shoes and I love being able to share my passion for them with others.